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Article

Genomic architecture and functional effects of potential human inversion supergenes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 1 Aug 2022

Campoy Elena, Puig Marta, Yakymenko Illya, Lerga-Jaso Jon, Cáceres Mario

Abstract excerpt

Supergenes are involved in adaptation in multiple organisms, but they are little known in humans. Genomic inversions are the most common mechanism of supergene generation and maintenance. Here, we review the information about two large inversions that are the best examples of potential human supergenes. In addition, we do an integrative analysis of the newest data to understand better their functional effects and...

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Chromosome Inversion
Genomics
Haplotypes
Phenotype
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35694745
DOI: 10.1098/rstb.2021.0209
PMCID: PMC9189494

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