Article
Mathematical modeling for mutator phenotype and clonal selection advantage in the risk analysis of lung cancer.
Theory in biosciences = Theorie in den Biowissenschaften - 1 Sept 2022
Li Lingling, Zhao Ting, He Xingshi, Yang Xinshe, Tian Tianhai, Zhang Xinan
Abstract excerpt
Cancer is one of the leading diseases for human mortality. Although substantial research works have been conducted to investigate the initiation and progression of cancer disease, it is still an active debate regarding the function of mutations conferring a clone advantage and the importance of mutator phenotypes caused by the mutation of stability genes. To address this issue further, we develop a mathematical...
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