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Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes

19 May 2022

Abstract excerpt

Interleukin (IL)-37 suppresses systemic and local inflammation. It is expressed in the epidermis, the external layer of the skin, and is decreased in inflammatory skin diseases including atopic dermatitis (AD) and psoriasis. Therefore, an agent applied topically on the skin that can increase IL-37 could be promising for treating AD and psoriasis; however, the mechanism regulating IL-37 remains largely unknown....

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PMID: 35663970
DOI: 10.3389/fimmu.2022.745997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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