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Article

Circulating Tumor DNA and Late Recurrence in High-Risk Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2022

Lipsyc-Sharf Marla, de Bruin Elza C, Santos Katheryn, McEwen Robert, Stetson Daniel, Patel Ashka, Kirkner Gregory J, Hughes Melissa E, Tolaney Sara M, Partridge Ann H, Krop Ian E, Knape Charlene, Feger Ute, Marsico Giovanni, Howarth Karen, Winer Eric P, Lin Nancy U, Parsons Heather A

Abstract excerpt

PURPOSE: To examine the prevalence and dynamics of circulating tumor DNA (ctDNA) and its association with metastatic recurrence in patients with high-risk early-stage hormone receptor-positive breast cancer (HR+ BC) more than 5 years from diagnosis. METHODS: We enrolled 103 patients with high-risk stage II-III HR+ BC diagnosed more than 5 years prior without clinical evidence of recurrence. We performed...

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Identifiers

PMID: 35658506
DOI: 10.1200/JCO.22.00908
PMCID: PMC9467679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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