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Article

Clonal Hematopoiesis and Mosaicism Revealed by a Multi-Tissue Analysis of Constitutional TP53 Status.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Aug 2022

Castillo Danielle, Yuan Tze-An, Nehoray Bita, Cervantes Aleck, Tsang Kevin K, Yang Kai, Sand Sharon R, Mokhnatkin Janet, Herzog Josef, Slavin Thomas P, Hyman Sophie, Schwartz Alison, Ebert Benjamin L, Amos Christopher I, Garber Judy E, Weitzel Jeffrey N

Abstract excerpt

BACKGROUND: Though germline TP53 pathogenic/likely pathogenic variants (PV) are associated with Li-Fraumeni syndrome, many detected by multigene panels represent aberrant clonal expansion (ACE), most due to clonal hematopoiesis (CH). Discerning ACE/CH from germline variants and postzygotic mosaicism (PZM) is critically needed for risk assessment and management. METHODS: Participants in the Li-Fraumeni & TP53...

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Identifiers

PMID: 35654360
DOI: 10.1158/1055-9965.EPI-21-1296
PMCID: PMC9866580

Genes

TP53
ACE
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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