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Mouse oocytes develop in cysts with the help of nurse cells

26 May 2022

Abstract excerpt

Mouse germline cysts, on average, develop into six oocytes supported by 24 nurse cells that transfer cytoplasm and organelles to generate a Balbiani body. We showed that between E14.5 and P5, cysts periodically activate some nurse cells to begin cytoplasmic transfer, which causes them to shrink and turnover within 2 days. Nurse cells die by a programmed cell death (PCD) pathway involving acidification, similar to...

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PMID: 35623357
DOI: 10.1016/j.cell.2022.05.001

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