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Article

Molecular evolution and structural analyses of the spike glycoprotein from Brazilian SARS-CoV-2 genomes: the impact of selected mutations.

Journal of biomolecular structure & dynamics - 1 Apr 2023

Gröhs Ferrareze Patrícia Aline, Zimerman Ricardo Ariel, Franceschi Vinícius Bonetti, Caldana Gabriel Dickin, Netz Paulo Augusto, Thompson Claudia Elizabeth

Abstract excerpt

The COVID-19 pandemic caused by SARS-CoV-2 has reached by February 2022 more than 380 million cases and 5.5 million deaths worldwide since its beginning in late 2019, leading to enhanced concern in the scientific community and the general population. One of the most important pieces of this host-pathogen interaction is the spike protein, which binds to the hACE2 cell receptor, mediates the membrane fusion and is...

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PMID: 35594172
DOI: 10.1080/07391102.2022.2076154

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