Article
Monocytosis and its association with clonal hematopoiesis in community-dwelling individuals.
Blood advances - 26 Jul 2022
van Zeventer Isabelle A, de Graaf Aniek O, Koorenhof-Scheele Theresia N, van der Reijden Bert A, van der Klauw Melanie M, Dinmohamed Avinash G, Diepstra Arjan, Schuringa Jan Jacob, Malcovati Luca, Huls Gerwin, Jansen Joop H
Abstract excerpt
Monocytosis may occur in numerous inflammatory conditions but is also the defining feature of chronic myelomonocytic leukemia (CMML). Clonal somatic mutations detectable in CMML may occur with aging in otherwise healthy individuals, so-called "clonal hematopoiesis" (CH). We investigated whether the combination of CH and monocytosis would represent an early developmental stage of CMML. We studied...
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