Article
Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2018
Asselah Tarik, Kowdley Kris V, Zadeikis Neddie, Wang Stanley, Hassanein Tarek, Horsmans Yves, Colombo Massimo, Calinas Filipe, Aguilar Humberto, de Ledinghen Victor, Mantry Parvez S, Hezode Christophe, Marinho Rui Tato, Agarwal Kosh, Nevens Frederik, Elkhashab Magdy, Kort Jens, Liu Ran, Ng Teresa I, Krishnan Preethi, Lin Chih-Wei, Mensa Federico J
Abstract excerpt
BACKGROUND & AIMS: Hepatitis C virus (HCV) has high genotypic diversity and global distribution. Agents that are effective against all major HCV genotypes, with shorter treatment duration, are needed to reduce disease burden. Glecaprevir (an NS3/4A protease inhibitor) and pibrentasvir (an NS5A inhibitor) have a high barrier to resistance and synergistic antiviral activity. We evaluated the safety and efficacy of...
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