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Article

Histone demethylase KDM5A regulates the functions of human periodontal ligament stem cells during periodontitis via the miR-495-3p/HOXC8 axis

22 Apr 2022

Abstract excerpt

Introduction: Periodontitis is the sixth most common human disease and epigenetic regulation is identified to affect the functions of stem cells. This research aims to analyze the role of histone demethylase Lysine-specific demethylase 5A (KDM5A) in human periodontal ligament stem cells (hPDLSCs) with periodontitis. Methods: hPDLSCs were treated with porphyromonas gingivalis-lipopolysaccharide (Pg-LPS) and...

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PMID: 35509266
DOI: 10.1016/j.reth.2021.12.002

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