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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

2 May 2022

Abstract excerpt

Abstract Background Estriol (E3) is a steroid hormone formed only during pregnancy in primates including humans. Although E3 is synthesized at large amounts through a complex pathway involving the fetus and placenta, it is not required for the maintenance of pregnancy and has classically been considered virtually inactive due to associated very weak canonical estrogen signaling. However, estrogen exposure during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35491423
DOI: 10.1186/s12915-022-01293-4

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