Article
An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L.
European journal of medicinal chemistry - 15 Jan 2024
Wang Xiuqi, DeFilippis Rosa Anna, Weldemichael Tsigereda, Gunaganti Naresh, Tran Phuc, Leung Yuet-Kin, Shah Neil P, Li Hong-Yu
Abstract excerpt
FLT3 activating mutations are detected in approximately 30 % of newly diagnosed acute myeloid leukemia (AML) cases, most commonly consisting of internal tandem duplication (ITD) mutations in the juxtamembrane region. Recently, several FLT3 inhibitors have demonstrated clinical activity and three...
Topics
- Humans
- Molecular Docking Simulation
- Protein Kinase Inhibitors
- Mutation
- Leukemia, Myeloid, Acute
- Pyridines
- fms-Like Tyrosine Kinase 3