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EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non‐endemic region

29 Apr 2022

Abstract excerpt

Nasopharyngeal carcinoma (NPC) is caused by infection with Epstein-Barr virus (EBV) and endemic in certain geographic regions. EBV lytic gene, BALF2, closely associates with viral reactivation and BALF2 gene variation, the H-H-H strain, causes NPC in endemic region, southern China. Here, we investigate whether such EBV variations also affect NPC in a non-endemic region, Japan. Viral genome sequencing with 47 EBV...

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PMID: 35485636
DOI: 10.1111/cas.15381

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