Article
Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§.
Systems biology in reproductive medicine - 1 Aug 2022
Vogt Peter H, Besikoglu Banu, Bettendorf Markus, Frank-Herrmann Petra, Zimmer Jutta, Bender Urike, Knauer-Fischer Sabine, Choukair Daniela, Sinn Peter, Doerr Helmuth-Guenther, Woelfle Joachim, Heidemann Peter H, Lau Yun-Fai Chris, Strowitzki Thomas
Abstract excerpt
"Differences of Sexual Development (DSD)," individuals with rearranged Y chromosome breaks in their 46,XY cells are reported with male and female gender phenotypes and differences in germ cell tumour (GCT) risk. This raised the question of whether male or female gender and GCT risk depends on the site of the break and/or rearrangement of the individual´s Y chromosome. In this paper, we report molecular mapping of...
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