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Universal lung epithelium DNA methylation markers for detection of lung damage in liquid biopsies

21 Apr 2022

Abstract excerpt

BACKGROUND: Circulating biomarkers for lung damage are lacking. Lung epithelium-specific DNA methylation patterns can potentially report the presence of lung-derived cell-free DNA (cfDNA) in blood, as an indication of lung cell death. METHODS: We sorted human lung alveolar and bronchial epithelial cells from surgical specimens, and obtained their methylomes using whole-genome bisulfite sequencing. We developed a...

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PMID: 35450968
DOI: 10.1183/13993003.03056-2021

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