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Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases

21 Apr 2022

Abstract excerpt

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and related to chronic kidney disease, hypertension, and pathogen defense. To gain insights into potential systemic roles, we performed genome-wide screens of circulating uromodulin using complementary antibody-based and aptamer-based assays. We...

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PMID: 35446786
DOI: 10.1172/jci.insight.157035

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