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Article

Generation and Characterization of iPS Cells Derived from APECED Patients for Gene Correction.

Frontiers in endocrinology - 1 Jan 2022

Karvonen Eira, Krohn Kai J E, Ranki Annamari, Hau Annika

Abstract excerpt

APECED (Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy) is a severe and incurable multiorgan autoimmune disease caused by mutations in the AIRE (autoimmune regulator) gene. Without functional AIRE, the development of central and peripheral immune tolerance is severely impaired allowing the accumulation of autoreactive immune cells in the periphery. This leads to multiple endocrine and...

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Identifiers

PMID: 35432216
DOI: 10.3389/fendo.2022.794327
PMCID: PMC9010864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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