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Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease

15 Apr 2022

Abstract excerpt

Abstract Rationale Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH) than in uninfected populations. Objectives To identify whether accelerated aging can be observed in the airways of PLWH with COPD, manifest by a unique DNA methylation signature. Methods Bronchial epithelial brushings from PLWH with and without...

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Share to Chronic Obstructive Pulmonary Disease (COPD) Research
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PMID: 35426765
DOI: 10.1164/rccm.202106-1440oc

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