Article
JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia.
Leukemia - 1 Jun 2022
Bodaar Kimberly, Yamagata Natsuko, Barthe Anais, Landrigan Jack, Chonghaile Triona Ni, Burns Melissa, Stevenson Kristen E, Devidas Meenakshi, Loh Mignon L, Hunger Stephen P, Wood Brent, Silverman Lewis B, Teachey David T, Meijerink Jules P, Letai Anthony, Gutierrez Alejandro
Abstract excerpt
Resistance to mitochondrial apoptosis predicts inferior treatment outcomes in patients with diverse tumor types, including T-cell acute lymphoblastic leukemia (T-ALL). However, the genetic basis for variability in this mitochondrial apoptotic phenotype is poorly understood, preventing its rational therapeutic targeting. Using BH3 profiling and exon sequencing analysis of childhood T-ALL clinical specimens, we...
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