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Article

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

29 Jul 2019

Abstract excerpt

Deregulated cell death pathways contribute to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Intrinsic apoptosis signaling is regulated by different proapoptotic and antiapoptotic molecules: proapoptotic BCL-2 homology domain 3 (BH3) proteins activate prodeath molecules leading to cellular death, while antiapoptotic molecules including B-cell lymphoma 2 (BCL-2)...

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PMID: 31358732
DOI: 10.1038/s41419-019-1801-0

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