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Article

Applying Protein-Protein Interactions and Complex Networks to Identify Novel Genes in Retinitis Pigmentosa Pathogenesis.

International journal of molecular sciences - 2 Apr 2022

Yoon Su-Bin, Ma Yu-Chien Calvin, Venkat Akaash, Liu Chun-Yu Audi, Zheng Jie J

Abstract excerpt

Retinitis Pigmentosa (RP) is a hereditary retinal disorder that causes the atrophy of photoreceptor rod cells. Since individual defective genes converge on the same disease, we hypothesized that all causal genes of RP belong in a complex network. To explore this hypothesis, we conducted a gene connection analysis using 161 genes attributed to RP, compiled from the Retinal Information Network, RetNet. We then...

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Identifiers

PMID: 35409321
DOI: 10.3390/ijms23073962
PMCID: PMC8999418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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