Article
Biallelic, Selectable, Knock-in Targeting of CCR5 via CRISPR-Cas9 Mediated Homology Directed Repair Inhibits HIV-1 Replication.
Frontiers in immunology - 1 Jan 2022
Scheller Stefan H, Rashad Yasmine, Saleh Fayez M, Willingham Kurtis A, Reilich Antonia, Lin Dong, Izadpanah Reza, Alt Eckhard U, Braun Stephen E
Abstract excerpt
Transplanting HIV-1 positive patients with hematopoietic stem cells homozygous for a 32 bp deletion in the chemokine receptor type 5 (CCR5) gene resulted in a loss of detectable HIV-1, suggesting genetically disrupting CCR5 is a promising approach for HIV-1 cure. Targeting the CCR5-locus with CRISPR-Cas9 was shown to decrease the amount of CCR5 expression and HIV-1 susceptibility in vitro as well as in vivo....
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