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Article

Association of TMPRSS2 Gene Polymorphisms with COVID-19 Severity and Mortality: a Case-Control Study with Computational Analyses.

Applied biochemistry and biotechnology - 1 Aug 2022

Rokni Mohsen, Heidari Nia Milad, Sarhadi Mohammad, Mirinejad Shekoufeh, Sargazi Saman, Moudi Mahdiyeh, Saravani Ramin, Rahdar Sara, Kargar Maryam

Abstract excerpt

Coronavirus disease 2019 (COVID-19) is a severe disease caused by a new variant of beta-coronavirus that first appeared in China. Human genetic factors, including polymorphisms, serve pivotal roles in the high transmission of SARS-CoV-2 and the stubbornly progressing sickness seen in a small but significant percentage of infected people; however, but these factors remain ill-defined. A total of 288 COVID-19...

Topics

Alleles
COVID-19
Case-Control Studies
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Single Nucleotide
SARS-CoV-2
Serine Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35386063
DOI: 10.1007/s12010-022-03885-w
PMCID: PMC8986508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-35386063-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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