Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis.

Journal of neuro-oncology - 1 May 2022

Liu Kevin X, Shang Helen H, Cacciotti Chantel, Everdell Emily, Aizer Ayal A, Rahman Rifaquat, Malinowski Seth, Meredith David M, Kamihara Junne, Wen Patrick Y, Ligon Keith L, Chi Susan N, Marcus Karen J, Yeo Kee Kiat, Alexandrescu Sanda, Haas-Kogan Daphne A

Abstract excerpt

PURPOSE: We sought to characterize clinical outcomes for adult and pediatric patients with primary CNS tumors harboring DICER1 mutations or loss of DICER1. METHODS: We conducted a retrospective cohort study of 98 patients who were treated between 1995 and 2020 for primary CNS tumors containing DICER1 mutations or loss of DICER1 on chromosome 14q, identified by targeted next generation sequencing. Kaplan-Meier...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System Neoplasms
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DEAD-box RNA Helicases

Share to Glioma

Share to Mutation

Share to Prognosis

Share to Ribonuclease III

Share to Sarcoma

Source

Identifiers

PMID: 35384518
DOI: 10.1007/s11060-022-03994-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis.PMID 35384518Read ↗

DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor.Semantic proximity Read ↗

Primary central nervous system sarcoma with DICER1 mutation-treatment results of a novel molecular entity in pediatric Peruvian patients.Semantic proximity Read ↗

[Primary intracranial DICER1-mutant sarcoma: a clinicopathological analysis of seven cases].Semantic proximity Read ↗

A Rare Adult Primary Intracranial Sarcoma, DICER1-Mutant Identified by Epigenomic Profiling: A Case ReportSemantic proximity Read ↗

Genomic characterization of DICER1-associated neoplasms uncovers molecular classes.Semantic proximity Read ↗

Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant.Semantic proximity Read ↗

Rare child primary intracranial sarcoma associated with DICER1 mutation: a case report and review of the literature.Semantic proximity Read ↗

All pineal tumors expressing germ cell tumor markers are not necessarily germ cell tumors: histopathological and molecular study of a midline primary intracranial sarcoma DICER1-mutant.Semantic proximity Read ↗

A Case of Primary Intracranial Sarcoma, DICER1-Mutant, in a Child with a Germline DICER1 MutationSemantic proximity Read ↗

DICER1-Associated Central Nervous System Sarcoma with Neural Lineage Differentiation: A Case ReportSemantic proximity Read ↗

Primary intracranial sarcoma associated with DICER1-mutant: A case report and preclinical investigationSemantic proximity Read ↗

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.