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Article

First detection of voltage-gated sodium channel mutations in Phlebotomus argentipes collected from Bangladesh.

Journal of vector borne diseases - 1 Jan 2000

Sarkar Santana R, Kuroki Akihiro, Özbel Yusuf, Osada Yasutaka, Omachi Satoko, Shyamal Paul K, Rahman Fashiur, Kasai Shinji, Noiri Eisei, Matsumoto Yoshitsugu, Sanjoba Chizu

Abstract excerpt

BACKGROUND & OBJECTIVES: Phlebotomus argentipes is the main vector of visceral leishmaniasis in Bangladesh and is controlled using deltamethrin, a synthetic pyrethroid, through indoor residual spraying (IRS). A mutation at L1014 (leucine at codon 1014) of the voltage-gated sodium channel (VGSC), known as a knockdown resistance (kdr) gene, is thought to be an important pyrethroid resistance mechanism. This study...

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PMID: 35381827
DOI: 10.4103/0972-9062.328972

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