Article
Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in the voltage gated Na+ channel of Anopheles culicifacies from Orissa, India.
Malaria journal - 28 May 2010
Singh Om P, Dykes Cherry L, Das Manoj K, Pradhan Sabyasachi, Bhatt Rajendra M, Agrawal Om P, Adak Tridibes
Abstract excerpt
BACKGROUND: Knockdown resistance in insects resulting from mutation(s) in the voltage gated Na+ channel (VGSC) is one of the mechanisms of resistance against DDT and pyrethroids. Recently a point mutation leading to Leu-to-Phe substitution in the VGSC at residue 1014, a most common kdr mutation in insects, was reported in Anopheles culicifacies-a major malaria vector in the Indian subcontinent. This study reports...
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