Article
E-Volve: understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces.
PeerJ - 1 Jan 2022
Dos Santos Vitor Pimentel, Rodrigues André, Dutra Gabriel, Bastos Luana, Mariano Diego, Mendonça José Gutembergue, Lobo Yan Jerônimo Gomes, Mendes Eduardo, Maia Giovana, Machado Karina Dos Santos, Werhli Adriano Velasque, Rocha Gerd, de Lima Leonardo Henrique França, de Melo-Minardi Raquel
Abstract excerpt
Background: The SARS-CoV-2 pandemic reverberated, posing health and social hygiene obstacles throughout the globe. Mutant lineages of the virus have concerned scientists because of convergent amino acid alterations, mainly on the viral spike protein. Studies have shown that mutants have diminished activity of neutralizing antibodies and enhanced affinity with its human cell receptor, the ACE2 protein. Methods:...
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