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Article

Aberrant Notch Signaling Pathway as a Potential Mechanism of Central Precocious Puberty.

International journal of molecular sciences - 19 Mar 2022

Shim Young Suk, Lee Hae Sang, Hwang Jin Soon

Abstract excerpt

The Notch signaling pathway is highly conserved during evolution. It has been well documented that Notch signaling regulates cell proliferation, migration, and death in the nervous, cardiac, and endocrine systems. The Notch pathway is relatively simple, but its activity is regulated by numerous complex mechanisms. Ligands bind to Notch receptors, inducing their activation and cleavage. Various post-translational...

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Mutation
Puberty
Puberty, Precocious
Receptors, Notch
Signal Transduction

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PMID: 35328752
DOI: 10.3390/ijms23063332
PMCID: PMC8950842

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