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p53 Immunohistochemistry and Mutation Types Mismatching in High-Grade Serous Ovarian Cancer

24 Feb 2022

Abstract excerpt

gene mutation. Missense or nonsense mutation types accompany most cases of HGSCa that correlate well with immunohistochemical (IHC) staining results-an all (missense) or none (nonsense) pattern. However, some IHCs produce subclonal or mosaic patterns from which TP53 mutation types, including the wild type of the gene, cannot be clearly deduced. We analyzed a total of 236 cases of ovarian HGSCa and tumors of other...

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PMID: 35328131
DOI: 10.3390/diagnostics12030579

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