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Article

Artificial Intelligence-Assisted Serial Analysis of Clinical Cancer Genomics Data Identifies Changing Treatment Recommendations and Therapeutic Targets.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2022

Fischer Catherine G, Pallavajjala Aparna, Jiang LiQun, Anagnostou Valsamo, Tao Jessica, Adams Emily, Eshleman James R, Gocke Christopher D, Lin Ming-Tseh, Platz Elizabeth A, Xian Rena R

Abstract excerpt

PURPOSE: Given the pace of predictive biomarker and targeted therapy development, it is unknown whether repeat annotation of the same next-generation sequencing data can identify additional clinically actionable targets that could be therapeutically leveraged. In this study, we sought to determine the predictive yield of serial reanalysis of clinical tumor sequencing data. EXPERIMENTAL DESIGN: Using artificial...

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Identifiers

PMID: 35312750
DOI: 10.1158/1078-0432.CCR-21-4061
PMCID: PMC9167716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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