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Article

Long Non-Coding RNAs H19 and HOTAIR Implicated in Intervertebral Disc Degeneration

3 Mar 2022

Abstract excerpt

Objective: Intervertebral disc degeneration (IDD) is the major cause of low back pain. We aimed to identify the key genes for IDD pathogenesis. Methods: An integrated analysis of microarray datasets of IDD archived in public Gene Expression Omnibus was performed. Bioinformatics analyses including identification of differentially expressed mRNAs/microRNAs/long non-coding RNAs (DEMs/DEMis/DELs), pathway enrichment,...

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PMID: 35309146
DOI: 10.3389/fgene.2022.843599

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