Article
Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4.
Auris, nasus, larynx - 1 Dec 2022
Murakoshi Michio, Koike Yuhi, Koyama Shin, Usami Shinichi, Kamiya Kazusaku, Ikeda Katsuhisa, Haga Yoichi, Tsumoto Kohei, Nakamura Hiroyuki, Hirasawa Noriyasu, Ishihara Kenji, Wada Hiroshi
Abstract excerpt
OBJECTIVE: Pendrin is a transmembrane protein encoded by the SLC26A4 gene that functions in maintaining ion concentrations in the endolymph of the inner ear, most likely by acting as a chloride/bicarbonate transporter. Variants in the SLC26A4 gene are responsible for sensorineural hearing loss. Although pendrin localizes to the plasma membrane, we previously identified that 8 missense allele products of SLC26A4...
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