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Article

Targeting the sarcomere in inherited cardiomyopathies.

Nature reviews. Cardiology - 1 Jun 2022

Lehman Sarah J, Crocini Claudia, Leinwand Leslie A

Abstract excerpt

Variants in >12 genes encoding sarcomeric proteins can cause various cardiomyopathies. The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Current therapeutics do not target the root causes of these diseases, but attempt to prevent disease progression and/or to manage symptoms. Accordingly, novel approaches are being developed to treat the cardiac muscle dysfunction...

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Share to Cardiomyopathies
Share to Cardiomyopathy, Dilated
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocardium

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Source

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Identifiers

PMID: 35304599
DOI: 10.1038/s41569-022-00682-0
PMCID: PMC9119933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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