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Novel Therapies for Prevention and Early Treatment of Cardiomyopathies

23 May 2019

Abstract excerpt

Heritable cardiomyopathies are a class of heart diseases caused by variations in a number of genetic loci. Genetic variants on one allele lead to either a degraded protein, which causes a haploinsufficiency of that protein, or a nonfunctioning protein that subverts the molecular system within which the protein works. Over years, both of these mechanisms eventually lead to diseased heart tissue and symptoms of a...

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PMID: 31120825
DOI: 10.1161/circresaha.119.313569

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