Article
Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study.
Cancer imaging : the official publication of the International Cancer Imaging Society - 18 Mar 2022
Clément Alexandra, Zaragori Timothee, Filosa Romain, Ovdiichuk Olga, Beaumont Marine, Collet Charlotte, Roeder Emilie, Martin Baptiste, Maskali Fatiha, Barberi-Heyob Muriel, Pouget Celso, Doyen Matthieu, Verger Antoine
Abstract excerpt
BACKGROUND: This translational study explores multi-tracer PET imaging for the non-invasive detection of the IDH1 mutation which is a positive prognostic factor in glioma. METHODS: U87 human high-grade glioma (HGG) isogenic cell lines with or without the IDH1 mutation (CRISP/Cas9 method) were stereotactically grafted into rat brains, and examined, in vitro, in vivo and ex vivo. PET imaging sessions, with...
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