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Childhood-Onset Hereditary Spastic Paraplegia (HSP): A Case Series and Review of Literature.

Pediatric neurology - 1 May 2022

Panwala Tanya F, Garcia-Santibanez Rocio, Vizcarra Joaquin A, Garcia Aixa Gonzalez, Verma Sumit

Abstract excerpt

BACKGROUND: Hereditary spastic paraplegia (HSP) encompasses several rare genetic disorders characterized by progressive lower extremity spasticity and weakness caused by corticospinal tract degeneration. Published literature on genetically confirmed pediatric HSP cases is limited. METHODS: We conducted a retrospective review of childhood-onset HSP cases followed in the neuromuscular clinics at Children's and...

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Child, Preschool
Exome Sequencing
Exoribonucleases
Kinesins
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spastic Paraplegia, Hereditary

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PMID: 35303589
DOI: 10.1016/j.pediatrneurol.2022.02.007

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