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Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants

1 Mar 2022

Abstract excerpt

Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD) may alter viral host tropism and affect the activities of neutralizing antibodies. Here, we investigated 153 RBD mutants and 11 globally circulating variants of concern (VOCs) and variants of interest (VOIs) (including Omicron) for their antigenic changes and cross-species tropism in cells expressing...

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PMID: 35303476
DOI: 10.1016/j.celrep.2022.110558

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