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Article

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

17 Mar 2022

Abstract excerpt

SignificanceHatching from the zona pellucida is a prerequisite for embryo implantation and is less likely to occur in vitro for reasons unknown. Extracellular vesicles (EVs) are secreted by the embryo into the culture medium. Yet the role that embryonic EVs and their cargo microRNAs (miRNAs) play in blastocyst hatching has not been elucidated, partially due to the difficulties of isolating them from low amounts...

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PMID: 35298333
DOI: 10.1073/pnas.2122708119

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