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Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation

17 Jun 2023

Abstract excerpt

STUDY QUESTION: Are the extracellular vesicles (EVs) secreted by the maternal endometrium uptaken by human embryos and is their miRNA cargo involved in implantation and embryo development? SUMMARY ANSWER: Data suggest that EVs secreted by human endometrial epithelial cells are internalized by human blastocysts, and transport miRNAs to modulate biological processes related to implantation events and early embryo...

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PMID: 37407281
DOI: 10.1093/humrep/dead138

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