Article
Screening for phenotypic outliers identifies an unusually low concentration of a β-lactoglobulin B protein isoform in bovine milk caused by a synonymous SNP.
Genetics, selection, evolution : GSE - 16 Mar 2022
Davis Stephen R, Ward Hamish E, Kelly Van, Palmer David, Ankersmit-Udy Alexandra E, Lopdell Thomas J, Berry Sarah D, Littlejohn Mathew D, Tiplady Kathryn, Adams Linda F, Carnie Katie, Burrett Alayna, Thomas Natalie, Snell Russell G, Spelman Richard J, Lehnert Klaus
Abstract excerpt
BACKGROUND: Milk samples from 10,641 dairy cattle were screened by a mass spectrometry method for extreme concentrations of the A or B isoforms of the whey protein, β-lactoglobulin (BLG), to identify causative genetic variation driving changes in BLG concentration. RESULTS: A cohort of cows, from a single sire family, was identified that produced milk containing a low concentration of the BLG B protein isoform. A...
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