Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes.

doi:10.1186/s13148-022-01257-z

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Article

Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes.

Clinical epigenetics - 12 Mar 2022

Seyres Denis, Cabassi Alessandra, Lambourne John J, Burden Frances, Farrow Samantha, McKinney Harriet, Batista Joana, Kempster Carly, Pietzner Maik, Slingsby Oliver, Cao Thong Huy, Quinn Paulene A, Stefanucci Luca, Sims Matthew C, Rehnstrom Karola, Adams Claire L, Frary Amy, Ergüener Bekir, Kreuzhuber Roman, Mocciaro Gabriele, D'Amore Simona, Koulman Albert, Grassi Luigi, Griffin Julian L, Ng Leong Loke, Park Adrian, Savage David B, Langenberg Claudia, Bock Christoph, Downes Kate, Wareham Nicholas J, Allison Michael, Vacca Michele, Kirk Paul D W, Frontini Mattia

Abstract excerpt

BACKGROUND: This work is aimed at improving the understanding of cardiometabolic syndrome pathophysiology and its relationship with thrombosis by generating a multi-omic disease signature. METHODS/RESULTS: We combined classic plasma biochemistry and plasma biomarkers with the transcriptional and epigenetic characterisation of cell types involved in thrombosis, obtained from two extreme phenotype groups (morbidly...

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Identifiers

PMID: 35279219
DOI: 10.1186/s13148-022-01257-z
PMCID: PMC8917653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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