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Article

Changing trends of splenectomy in hereditary spherocytosis: The experience of a reference Centre in the last 40 years.

British journal of haematology - 1 Sept 2022

Vercellati Cristina, Zaninoni Anna, Marcello Anna P, Fermo Elisa, Fattizzo Bruno, Giannotta Juri A, Bianchi Paola, Zanella Alberto, Barcellini Wilma

Abstract excerpt

We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011-2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressively increased (63% in children before 1990 to 88% in patients aged ≥20 years in 2011-2020). Our...

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PMID: 35277856
DOI: 10.1111/bjh.18106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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