Article
SPATA18 Expression Predicts Favorable Clinical Outcome in Colorectal Cancer.
International journal of molecular sciences - 2 Mar 2022
Sugimura-Nagata Akane, Koshino Akira, Nagao Kazuhiro, Nagano Aya, Komura Masayuki, Ueki Akane, Ebi Masahide, Ogasawara Naotaka, Tsuzuki Toyonori, Kasai Kenji, Takahashi Satoru, Kasugai Kunio, Inaguma Shingo
Abstract excerpt
Dysregulation of mitochondrial quality control has been reported to be associated with cancer and degenerative diseases. SPATA18 (spermatogenesis-associated 18, also known as Mieap) encodes a p53-inducible protein that can induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins and has tumor suppressor functions in mitochondrial quality control. In the present study, 268...
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