Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of SPATA2 in TNF signaling, cancer, and spermatogenesis

19 Nov 2022

Abstract excerpt

The activation of TNF receptors can lead to cell death with a mechanism of cell necrosis regulated genetically and distinct from apoptosis which is defined as necroptosis. Necroptosis has been one of the most studied emerging cell death/signaling pathways in recent years, especially in light of the role of this process in human disease. However, not all regulatory components of TNF signaling have been identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to Hedgehog Signaling Pathway Studies
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36402749
DOI: 10.1038/s41419-022-05432-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of SPATA2 in TNF signaling, cancer, and spermatogenesisPMID 36402749Read ↗

Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice†Semantic proximity Read ↗

The Story of SPATA2 (Spermatogenesis-Associated Protein 2): From Sertoli Cells to Pancreatic Beta-CellsSemantic proximity Read ↗

SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63Semantic proximity Read ↗

SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinomaSemantic proximity Read ↗

Identification and validation of CCL2 as a potential biomarker relevant to mast cell infiltration in the testicular immune microenvironment of spermatogenic dysfunctionSemantic proximity Read ↗

Spastin is an essential regulator of male meiosis, acrosome formation, manchette structure and nuclear integritySemantic proximity Read ↗

Identification of a novel pyroptosis-related gene signature in human spermatogenic dysfunctionSemantic proximity Read ↗

PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT PathwaysSemantic proximity Read ↗

Characterization of the role of tumor necrosis factor apoptosis inducing ligand (TRAIL) in spermatogenesis through the evaluation of trail gene-deficient mice.Semantic proximity Read ↗

SPATA4 improves aging‐induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansionSemantic proximity Read ↗

Cloning and Characterization of Testis-Specific Spermatogenesis Associated Gene Homologous to Human SPATA4 in RatSemantic proximity Read ↗

miRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.