Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System

24 Feb 2022

Abstract excerpt

The initial step in bacterial infection is adherence of the bacterium to the target cell surface. Helicobacter pylori exploits the interaction of bacterial adhesin protein HopQ with human epithelial CEACAMs (CEACAM1, 5, and 6) to stably adhere to gastric epithelial cells, which is necessary for delivery of the H. pylori CagA oncoprotein into the epithelial cells via a type IV secretion system. In contrast to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Esophagitis
Share to Gastroesophageal reflux and treatments
Share to Helicobacter pylori-related gastroenterology studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35269634
DOI: 10.3390/ijms23052492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion SystemPMID 35269634Read ↗

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagASemantic proximity Read ↗

Effects of Helicobacter pylori adhesin HopQ binding to CEACAM receptors in the human stomachSemantic proximity Read ↗

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMsSemantic proximity Read ↗

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMsSemantic proximity Read ↗

Disruption of the Epithelial Apical-Junctional Complex by <i>Helicobacter pylori</i> CagASemantic proximity Read ↗

Expression of CEACAM1 or CEACAM5 in AZ-521 cells restores the type IV secretion deficiency for translocation of CagA byHelicobacter pyloriSemantic proximity Read ↗

Identification of Pathogenicity Island Genes Associated with Loss of Type IV Secretion Function during Murine Infection with Helicobacter pyloriSemantic proximity Read ↗

The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagASemantic proximity Read ↗

Helicobacter pylori infection in mice: Role of outer membrane proteins in colonization and inflammation.Semantic proximity Read ↗

Adherence and invasion of mouse-adapted H pylori in different epithelial cell lines.Semantic proximity Read ↗

Generation of Human CEACAM1 Transgenic Mice and Binding of Neisseria Opa Protein to Their NeutrophilsSemantic proximity Read ↗

CagA Associates with c‐Met, E‐Cadherin, and p120‐Catenin in a Multiproteic Complex That SuppressesHelicobacter pylori–Induced Cell‐Invasive PhenotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.