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Purely electrical SARS-CoV-2 sensing based on single-molecule counting

1 Jan 2022

Abstract excerpt

The majority of RNA based COVID-19 diagnostics employ enzymatic amplification to achieve high sensitivity, but this relies on arbitrary thresholding, which complicates the comparison of test results and may lead to false outcomes. Here we introduce solid-state nanopore sensing for label-free quantification of SARS-CoV-2 RNA in clinical nasal swab samples. This PCR-free method involves reverse transcribing a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35258059
DOI: 10.1039/d1nr07787b

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