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Article

Li-Fraumeni syndrome in Tunisian carriers with different and rare tumor phenotype: genotype-phenotype correlation.

BMC medical genomics - 4 Mar 2022

Sassi Hela, Meddeb Rym, Cherif Mohamed Aziz, Nasr Chiraz, Riahi Aouatef, Hannachi Samia, Belguith Neila, M'rad Ridha

Abstract excerpt

BACKGROUND: Li-Fraumeni syndrome (LFS) is a rare autosomal hereditary predisposition to multiples cancers, mainly affecting young individuals. It is characterized by a broad tumor spectrum. To our best knowledge, only one Tunisian study with a confirmed LFS was published. METHODS: Our study focused on the clinical, histopathological and genetic results of two patients with rare tumor phenotype and tried to...

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Identifiers

PMID: 35246108
DOI: 10.1186/s12920-022-01189-w
PMCID: PMC8895785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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