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Article

NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma

2 Mar 2022

Abstract excerpt

Multiple myeloma (MM) remains an incurable plasma cell cancer characterized by abnormal secretion of monoclonal immunoglobulins. The molecular mechanism that regulates the drug sensitivity of MM cells is being intensively studied. Here, we report an unexpected finding that the protein encoded by neural precursor cell-expressed developmentally downregulated gene 4L (NEDD4L), which is a HECT E3 ligase, binds the...

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PMID: 35236820
DOI: 10.1038/s41419-022-04629-8

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