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Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization

2 Mar 2022

Abstract excerpt

BACKGROUND: EGFR targeting is currently the main treatment strategy for metastatic colorectal cancer (mCRC). Results of different clinical trials show that patients with wild-type KRAS and BRAF benefit from anti-EGFR monoclonal antibodies (moAbs) cetuximab (CTX) or panitumumab. Unfortunately, despite initial response, patients soon became refractory. Tumor heterogeneity and multiple escaping routes have been...

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PMID: 35236282
DOI: 10.1186/s11658-022-00319-7

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