Article
Identification and management of GCK-MODY complicating pregnancy in Chinese patients with gestational diabetes.
Molecular and cellular biochemistry - 1 May 2022
Jiang Yanyan, Jiang Fusong, Li Ming, Wu Qingkai, Xu Chenming, Zhang Rong, Song Mingqiang, Wang Yanzhong, Wang Ying, Chen Yating, Zhang Juan, Ge Xiaoxu, Zhu Qihan, Zhuang Langen, Yang Di, Lu Ming, Wang Feng, Jiang Meisheng, Liu Xipeng, Liu Yanjun, Liu Limei
Abstract excerpt
Precise differentiation of glucokinase (GCK) monogenic diabetes from gestational diabetes mellitus (GDM) is critical for accurate management of the pregnancy outcome. We screened GCK-MODY complicating pregnancies in Chinese GDM patients, explored the pathogenesis of novel GCK mutations, and evaluated the patients' pregnancy outcome and management. The GCK gene from 411 GDM patients was screened with PCR-direct...
Topics
- China
- Diabetes Mellitus, Type 2
- Diabetes, Gestational
- Female
- Glucokinase
- Humans
- Insulin
- Mutation
- Pregnancy
- Pregnancy Outcome